Home Antibody All anti-NOL3 antibodies
Also for NOL3 (NM_003946)
|ARC antibody was raised against a peptide corresponding to amino acids 191 to 208 of human origin.|
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3), transcript variant 2|
|ARC; FCM; MYP; NOP; NOP30|
Entrez Gene 8996 Human
|Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1).|
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Western blot analysis of ARC in HeLa (H), KB (K), and A549 (A) whole cell lysates with ARC antibody at 1:1000 dilution. 1st Below: Immunohistochemistry of ARC in human heart tissue at 5 µg/ml. 2nd Below: Immunohistochemistry of ARC in human skeletal muscle with ARC antibody at 5 µg/ml.
Immunohistochemistry of ARC in human skeletal muscle with ARC antibody at 5 ug/ml.