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Home Antibody All anti-DNASE2 antibodies

Anti-DNASE2 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA305979 Rabbit Polyclonal DNase II Antibody 100ug $325 3-7 Days
LC419982 DNASE2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for DNASE2 (NM_001375)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenDNase II antibody was raised against a peptide corresponding to amino acids 347 to 360 of human DNase II precursor (2-4) .
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 ug/mL, IHC: 5 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens deoxyribonuclease 2, lysosomal (DNASE2)
Alternative NameDNASE2A; DNL; DNL2
Database LinkNP_001366
Entrez Gene 1777 Human
FunctionApoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins including AIF and Acinus . DNase II causes both chromatin condensation and DNA fragmentation . The genes encoding human (2-4), porcine (4), and murine (5) DNase II have been cloned. The DNase II gene encodes a 40 kDa proenzyme. The mature enzyme consists of two non-identical subunits, the 32 kDa (a) and 12 kDa (b) chains, generated by proteolytic processing. Overexpression of DNase II induces chromatin condensation (3). DNase II is ubiquitously expressed in human tissues.
Related PathwayDruggable Genome Lysosome

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DNase II in human spleen tissue lysate in the absence (lane 1) or presence (lane 2) of blocking peptide with DNase antibody II at 1:500 dilution.

IHC Image
Immunohistochemistry of DNaseII in human spleen tissue with DNaseII antibody at 5 ug/ml.


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