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Home Antibody All anti-Dffa antibodies

Anti-Dffa Antibody

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SKU Description Amount Price Availability*  
TA305969
  • Rabbit Polyclonal ICAD Antibody
100ug $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenICAD antibody was raised against a peptide corresponding to amino acids 312 to 331 of mouse ICAD .
Clone Name IsotypeIgG
Species ReactivityMouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1:500 - 1:2000
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameMus musculus DNA fragmentation factor, alpha subunit (Dffa), transcript variant 2
Alternative NameA330085O09Rik; DFF35; Dff45; ICAD; ICAD-L; ICAD-S
Database LinkNP_034174
FunctionApoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human DNA fragmentation factor (DFF) was identified recently which was cleaved by caspase-3 during apoptosis. Mouse homologue of human DFF was identified as a DNase inhibitor designated ICAD, for inhibitor of caspase-activated DNase. Upon cleavage of DFF/ICAD, a caspase activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of CAD inhibitor molecule DFF/ICAD, which causes DNase activation and DNA degradation, is the hallmark of apoptotic cell death.
Related Pathway

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WB Image
Western blot analysis of ICAD in mouse lung (L), brain (B), liver (L), and kidney tissue lysate with CAD antibody at 1:1000 dilution.

 

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