Home Antibody All anti-TNFRSF10A antibodies
Also for TNFRSF10A (NM_003844)
|DR4 antibody was raised against a peptide corresponding to amino acid 1 to 20 of human DR4 mature protein.|
||WB: 1:500 - 1:1000
|PBS containing 0.02% sodium azide.|
|Antibody is DEAE purified
|Homo sapiens tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A)|
|APO2; CD261; DR4; TRAILR-1; TRAILR1|
Entrez Gene 8797 Human
|Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4)1. The ligand for this novel death receptor has been identified and termed TRAIL2,3, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1)4. DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kappaB activation in many tissues and cells.|
|TransmembraneDruggable Genome Cytokine-cytokine receptor interactionApoptosisNatural killer cell mediated cytotoxicity|
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Western blot analysis of DR4 in HeLa (H), K562 (K), and Jurkat (J) whole cell lysate with DR4 antibody at 1:500 dilution.