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Home Antibody All anti-MAP3K5 antibodies

Anti-MAP3K5 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA305959 Rabbit Polyclonal ASK1 Antibody 100ug $325 3-7 Days
LC401794 MAP3K5 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for MAP3K5 (NM_005923)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenASK1 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human ASK1 This sequence is different from that of mouse by last two amino acids.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 0.5 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL,
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
Alternative NameASK1; MAPKKK5; MEKK5
Database LinkNP_005914
Entrez Gene 4217 Human
FunctionMitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-alpha-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayNeurotrophin signaling pathwayAmyotrophic lateral sclerosis (ALS)

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of ASK1 in SW1353 whole cell lysate with ASK1 antibody at 1:500 dilution.

IF Image
Immunocytochemistry of ASK1 in A431 cells with ASK1 antibody at 10 ug/mL.

IF Image
Immunofluorescence of ASK1 in A431 cells with ASK1 antibody at 20 ug/mL.


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