Home Antibody All anti-Gfra3 antibodies
Also for Gfra3 (NM_001496)
|GFR alpha 3 antibody was raised against a peptide corresponding to amino acids from 347 to 360 of murine GFR alpha 3.|
|Human, Mouse, Rat
||WB: 1:500 - 1:1000
|PBS containing 0.02% sodium azide.|
|Antibody is DEAE purified
|Homo sapiens GDNF family receptor alpha 3 (GFRA3)|
|Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRalpha and Ret receptor tyrosine kinase GFRbeta (2). Following the findings of GFRΑ-1 and -2, a novel receptor in GFRalpha family was identified very recently from human and mouse and designated GFRalpha-3. GFRalpha-3 binds persephin, thus, persephin, GFRalpha-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.|
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Western blot analysis of GFR alpha 3 in crude cell membrane fractions of mouse heart (H), spleen (S), kidney (K), liver (L), and brain (B), respectively, with GFR alpha 3 antibody at 1:500 dilution.
Immunohistochemistry of GFRa-3 in mouse heart tissue with GFRa-3 antibody at 10 ug/ml.