Home Antibody All anti-CCR3 antibodies
Also for CCR3 (NM_001164680)
|CCR3 antibody was raised against a 14 amino acid peptide from near the amino terminus of human CCR3.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Immunoaffinity purified IgG (Protein A or G Sepharose)
|Homo sapiens chemokine (C-C motif) receptor 3 (CCR3), transcript variant 4|
|CC-CKR-3; CD193; CKR3; CMKBR3|
|Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells (1-4). CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS (3,4). High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems (5). The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 plays an important role in HIV infection of CNS.|
Cytokine-cytokine receptor interaction
Signaling by GPCR
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Western blot analysis of CCR3 in human spleen tissue lysates with CCR3 antibody at 1 (lane 1) and 2 µg/ml (lane 2), and 2 µg/ml in the presence of blocking peptide (lane 3).