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Home Antibody All anti-DIO2 antibodies

Anti-DIO2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305836
  • Goat Anti-DIO2 Antibody
100ug 325 3-7 Days
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IHC(1)

OriGene Data

ImmunogenPeptide with sequence EVKKHQNQEDRC, from the internal region of the protein sequence according to NP_000784.2; NP_054644.1; NP_001007024.1.
Clone Name IsotypeGoat IgG
Species ReactivityTest: Mouse. Expected from seq similarity: Human, Mouse, Rat, Pig Concentration0.5 mg/ml
Guaranteed Application *IHC Suggested DilutionsIHC: 2-3ug/ml.
Buffer0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens deiodinase, iodothyronine, type II (DIO2), transcript variant 2
Alternative Name5DII; D2; DIOII; SelY; TXDI2
Database LinkNP_000784
Entrez Gene 1734 Human
Entrez Gene 13371 Mouse
Entrez Gene 65162 Rat
FunctionThe protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
TA305836 (2ug/ml) staining of PFA-fixed cryo-sectioned Mouse Hippocampus. Microwaved antigen retrieval with citrate buffer pH 4.5, HRP-staining.

 

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