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Home Antibody All anti-AXIN1 antibodies

Anti-AXIN1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305807
  • Goat Anti-AXIN1 Antibody
100ug 325 3-7 Days
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IHC(1)

OriGene Data

ImmunogenPeptide with sequence C-FEEKIIGKVEKVD, from the C Terminus of the protein sequence according to NP_003493.1; NP_851393.1.
Clone Name IsotypeGoat IgG
Species ReactivityHuman, Mouse, Rat, Dog, Cow Concentration0.5 mg/ml
Guaranteed Application *IHC Suggested DilutionsIHC: 3-5ug/ml.
Buffer0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens axin 1 (AXIN1), transcript variant 1
Alternative NameAXIN; PPP1R49
Database LinkNP_003493
FunctionThis gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq].
Related Pathway
TGF Beta Signaling Pathway
Wnt Signaling Pathway

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IHC Image
TA305807 (3.8ug/ml) staining of paraffin embedded Human Adrenal Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

 

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