Home Antibody All anti-ALS2 antibodies
Also for ALS2 (NM_020919)
|Peptide with sequence LKACYYQIQREKLN, from the C Terminus of the protein sequence according to NP_065970.2.|
|Test: Human. Expected from seq similarity: Human, Mouse, Rat, Dog, Cow
|0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.
|Homo sapiens amyotrophic lateral sclerosis 2 (juvenile) (ALS2), transcript variant 1|
|ALS2CR6; ALSJ; IAHSP; PLSJ|
Entrez Gene 57679 Human
Entrez Gene 74018 Mouse
Entrez Gene 363235 Rat
Entrez Gene 100856109 Dog
|The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
|Druggable Genome Amyotrophic lateral sclerosis (ALS)|
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TA305806 (3.8ug/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.