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Home Antibody All anti-PSMB8 antibodies

Anti-PSMB8 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305716
  • Goat Anti-LMP7 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418176) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for PSMB8 (NM_004159)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPeptide with sequence C-DVSDLLHQYREANQ, from the C-Terminus of the protein sequence according to NP_004150.1; NP_683720.2.
Clone Name IsotypeGoat IgG
Species ReactivityHuman, Mouse, Rat, Dog, porcine, Cow Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.01-0.03ug/ml.
Buffer0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens proteasome (prosome, macropain) subunit, beta type, 8 (PSMB8), transcript variant 1
Alternative NameALDD; D6S216; D6S216E; JMP; LMP7; NKJO; PSMB5i; RING10
Database LinkNP_004150
FunctionThe proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq].
Related Pathway
Cell cycle

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WB Image
TA305716 (0.01ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

 

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