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Anti-LAT Antibody Y109
|A synthetic peptide corresponding to residues surrounding GRB2-binding motif 2 of human LAT was used as immunogen. This antibody detects both long and short forms of LAT.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500; IHC-P: Use at an assay dependent dilution; FC: 1:40; IP: 1:60
|Does not react with Mouse, Rat. Is unsuitable for ICC.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for ICC.
|Homo sapiens linker for activation of T cells (LAT), transcript variant 1|
|The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]. |
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Western blot - LAT antibody [Y109]; Anti-LAT antibody [Y109] at 1/500 dilution + Jurkat cell lysate.Predicted band size : 28 kDa.Observed band size : 35 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - LAT antibody [Y109]; Ab32070, at a dilution of 1/100, staining LAT in paraffin embedded human lymph node tissue by Immunohistochemistry.