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Anti-LAT Antibody Y109

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SKU Description Amount Price Availability*  
TA303861
  • Rabbit monoclonal antibody against LAT(Y109)
100ul $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding GRB2-binding motif 2 of human LAT was used as immunogen. This antibody detects both long and short forms of LAT.
Clone NameY109 IsotypeRabbit IgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500; IHC-P: Use at an assay dependent dilution; FC: 1:40; IP: 1:60
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC.

Reference Data

Target NameHomo sapiens linker for activation of T cells (LAT), transcript variant 1
Alternative NameLAT1; pp36
Database LinkNP_055202
Entrez Gene 27040 Human
FunctionThe protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Related PathwayTransmembraneDruggable Genome Natural killer cell mediated cytotoxicityT cell receptor signaling pathwayFc epsilon RI signaling pathwayFc gamma R-mediated phagocytosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - LAT antibody [Y109]; Anti-LAT antibody [Y109] at 1/500 dilution + Jurkat cell lysate.Predicted band size : 28 kDa.Observed band size : 35 kDa .
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - LAT antibody [Y109]; Ab32070, at a dilution of 1/100, staining LAT in paraffin embedded human lymph node tissue by Immunohistochemistry.
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