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Home Antibody All anti-RB1 antibodies

Anti-RB1 PHOSPHO Antibody E231

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SKU Description Amount Price Availability*  
TA303683 Rabbit monoclonal antibody against Rb Phospho (pT821) (E231 ) (phospho-specific) 100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Thr821 of human Rb was used as immunogen. The antibody only detects Rb phosphorylated on Threonine 821.
Clone NameE231 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:100; IP: 1:20
Predicted MW Explanation 106 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens retinoblastoma 1 (RB1)
Alternative NameOSRC; p105-Rb; pp110; pRb; RB
Database LinkNP_000312
Entrez Gene 5925 Human
FunctionThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq].
Related PathwayTranscription FactorsDruggable Genome Cell cyclePathways in cancerPancreatic cancerGliomaProstate cancerMelanomaMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

 

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