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Anti-RB1 PHOSPHO Antibody E231
|A synthetic phospho-peptide corresponding to residues surrounding Thr821 of human Rb was used as immunogen. The antibody only detects Rb phosphorylated on Threonine 821.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC/IF: 1:100; IP: 1:20
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Does not react with Mouse, Rat
|Homo sapiens retinoblastoma 1 (RB1)|
|OSRC; p105-Rb; pp110; pRb; RB|
|The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq]. |
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Western blot - Rb (phospho T821) antibody [E231]; All lanes : Anti-Rb (phospho T821) antibody [E231] at 1/1000 dilution.Lane 1 : Jurkat cell lysate, untreated.Lane 2 : Jurkat cell lysate treated with Phosphatase.Predicted band size : 106 kDa.Observed band size : 110 kDa .
Immunofluorescence - Rb (phospho T821) antibody [E231]; Ab32015, at a 1/100 dilution, staining Rb in HeLa cells by Immunofluorescence.