The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq].
Senescence and Autophagy
TGF Beta Signaling Pathway
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Western blot analysis on Jurkat cell lysate using anti-Phospho-Rb (S780) RabMAb (TA303682), 1:1000 dilution. Cells were (1) untreated or (2) treated with FBS. (3) Cell lysate was treated with Alkaline Phosphatase.
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