Homo sapiens protein tyrosine phosphatase, non-receptor type 1 (PTPN1)
Synonyms:
PTP1B
Immunogen
A phospho-specific peptide corresponding to residues surrounding serine 378 of human PTP1B was used as an immunogen. This antibody detects PTP1B phosphorylated on serine 378.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq].
Related Pathway
Adherens junction
Hemostasis
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Western blot analysis on HeLa cell lysates using anti-Phospho-PTP1B (pS378) RabMAb (TA303675), 1:1,000,000 dilution. Cells were either (A) untreated (B) treated with calyculin A
