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Anti-PTPN1 PHOSPHO Antibody EP1840Y
Also for PTPN1 (NM_002827)
|A phospho-specific peptide corresponding to residues surrounding serine 378 of human PTP1B was used as an immunogen. This antibody detects PTP1B phosphorylated on serine 378.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500,000 -1,000,000; IHC: 1:50 -100; ICC: 1:100 - 250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens protein tyrosine phosphatase, non-receptor type 1 (PTPN1), transcript variant 1|
Entrez Gene 5770 Human
|The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq]. |
|TransmembranePhosphataseDruggable Genome Adherens junctionInsulin signaling pathway|
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Western blot - PTP1B (phospho S378) antibody [EP1840Y]; All lanes : Anti-PTP1B (phospho S378) antibody [EP1840Y] at 1/1000000 dilution.Lane 1 : HeLa cell lysates - untreated.Lane 2 : HeLa cell lysates - treated with calyculin A.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/1000 dilution.Predicted band size : 50 kDa.Observed band size : 50 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PTP1B (phospho S378) antibody [EP1840Y]; TA303675, at a 1/50 dilution, staining human PTP1B (phospho S378) in breast carcinoma by Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.