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Anti-PRKCQ Antibody EPR1488Y
Also for PRKCQ (NM_006257)
|A synthetic peptide corresponding to residues surrounding Tyrosine 538 of human PKC theta was used as an immunogen. This antibody detects both phosphorylated (pT538) and unphosphorylated PKC theta.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens protein kinase C, theta (PRKCQ), transcript variant 1|
Entrez Gene 5588 Human
Entrez Gene 18761 Mouse
Entrez Gene 85420 Rat
|Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq]. |
|Protein KinaseTranscription FactorsDruggable Genome Vascular smooth muscle contractionTight junctionT cell receptor signaling pathwayAdipocytokine signaling pathway|
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Western blot - PKC theta antibody [EPR1488Y]; Anti-PKC theta antibody [EPR1488Y] at 1/500 dilution + Jurkat cell lysate at 10 ug.Secondary.HRP labeled goat anti-rabbit at 1/2000 dilution.Predicted band size : 85 kDa.Observed band size : 85 kDa.