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Anti-GRIA2 Antibody EP966Y
Also for GRIA2 (NM_000826)
|A synthetic peptide corresponding to a residue near N-term of human Glutamate receptor type 2 was used as immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:2000; IP: 1:40; FC: 1:30
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for ICC/IF,IHC-Fr or IHC-P.
|Homo sapiens glutamate receptor, ionotropic, AMPA 2 (GRIA2), transcript variant 1|
|GluA2; GluR-K2; GLUR2; GLURB; HBGR2|
Entrez Gene 2891 Human
Entrez Gene 14800 Mouse
Entrez Gene 29627 Rat
|Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq]. |
|TransmembraneIon Channels: Glutamate ReceptorsDruggable Genome Neuroactive ligand-receptor interactionLong-term potentiationLong-term depressionAmyotrophic lateral sclerosis (ALS)|
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Western blot - GluR2 antibody [EP966Y]; Anti-Ionotropic Glutamate receptor 2 antibody [EP966Y] at 1/2000 dilution + Human brain cell lysate at 10 ug.Secondary.Goat anti-Rabbit HRP labeled at 1/2000 dilution.Predicted band size : 99 kDa.Observed band size : 110 kDa .
Western blot - Anti-Ionotropic Glutamate receptor 2 antibody [EP966Y]; All lanes : Anti-Ionotropic Glutamate receptor 2 antibody [EP966Y] at 1/500 dilution.Lane 1 : Human Brain.Lane 2 : Rat Brain.Lane 3 : Mouse Brain.Predicted band size : 99 kDa.