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Home Antibody All anti-FOLH1 antibodies

Anti-FOLH1 Antibody EP3253

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303519
  • Rabbit monoclonal antibody against PSMA (EP3253 )
  • FREE positive control: HEK293T cell transient overexpression lysate (LC423102) , 20ug
100ul $325 In Stock
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WB(1)
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Also for FOLH1 (NM_001014986)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human PSMA was used as an immunogen.
Clone NameEP3253 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:5000; IP: 1:10; FC: 1:60
BufferDoes not react with Mouse, Rat. Is unsuitable for IHC-P.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IHC-P.

Reference Data

Target NameHomo sapiens folate hydrolase (prostate-specific membrane antigen) 1 (FOLH1), transcript variant 2
Alternative NameFGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA
Database LinkNP_001014986
FunctionThis gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq].
Related Pathway

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WB Image
Western blot - PSMA antibody [EP3253]; Anti-PSMA antibody [EP3253] at 1/5000 dilution + LnCaP cell lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/1000 dilution.Predicted band size : 84 kDa.Observed band size : 110 kDa .

 

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