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Home Antibody All anti-FOLH1 antibodies

Anti-FOLH1 Antibody EP3253

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA303519 Rabbit monoclonal antibody against PSMA (EP3253 ) 100ul $325 In Stock
LC423102 FOLH1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human PSMA was used as an immunogen.
Clone NameEP3253 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:5000; IP: 1:10; FC: 1:60
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IHC-P.

Reference Data

Target NameHomo sapiens folate hydrolase (prostate-specific membrane antigen) 1 (FOLH1), transcript variant 2
Alternative NameFGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA
Database LinkNP_001014986
Entrez Gene 2346 Human
FunctionThis gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq].
Related PathwayTransmembraneProteaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - PSMA antibody [EP3253]; Anti-PSMA antibody [EP3253] at 1/5000 dilution + LnCaP cell lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/1000 dilution.Predicted band size : 84 kDa.Observed band size : 110 kDa .
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