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Home Antibody All anti-ERBB4 antibodies

Anti-ERBB4 PHOSPHO Antibody EPR2271Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303504
  • Rabbit monoclonal antibody against HER4 / ErbB4 Phospho (pY1188) (EPR2271Y ) (phospho-specific)
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 1188 of human Her4 was used as an immunogen. This antibody detects Her4 phosphorylated on tyrosine 1188.
Clone NameEPR2271Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1,000; ICC: 1:100
Predicted MW Explanation 147 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 (ERBB4), transcript variant JM-a/CVT-1
Alternative NameALS19; HER4; p180erbB4
Database LinkNP_005226
Entrez Gene 2066 Human
FunctionThis gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq].
Related PathwayProtein KinaseTransmembraneDruggable Genome ErbB signaling pathwayCalcium signaling pathwayEndocytosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - ErbB 4 (phospho Y1188) antibody [EPR2271Y]; All lanes : Anti-ErbB 4 (phospho Y1188) antibody [EPR2271Y] at 1/2000 dilution.Lane 1 : A431 cell lysate. Cells untreated.Lane 2 : A431 cell lysate. Cells treated with EGF.Lysates/proteins at 10 ug per lane.Secondary.HRP conjugated Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 147 kDa.Observed band size : 170-200 kDa .

 

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