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Home Antibody All anti-AKT1 antibodies

Anti-AKT1 Antibody E45

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303388
  • Rabbit monoclonal antibody against Akt1/PKBa(E45)
100ul 325 In Stock
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IHC(1)
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Also for AKT1 (NM_005163)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding Ser473 of human Akt1 was used as immunogen. The antibody can detects Akt1 and Akt3. Predicted to cross-react with mouse, rat and bovine, based on sequence homology.
Clone NameE45 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *IHC Suggested DilutionsIHC: 1:1,000-1:2,500; ICC: 1:1,000; IP: 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction

Reference Data

Target NameHomo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 1
Alternative NameAKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA
Database LinkNP_005154
FunctionThe serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
Related Pathway
Apoptosis
Delta-Notch Signaling Pathway
EGFR1 Signaling Pathway
Focal Adhesion
Hemostasis
Jak-STAT signaling pathway
MAPK signaling pathway
Signaling by GPCR
Toll-like receptor signaling pathway
Wnt Signaling Pathway

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IHC Image
Immunohistochemistry (Paraffin-embedded sections) - AKT1 antibody [E45]; Immunohistochemistry (Paraffin-embedded sections) analysis using TA303388 at a dilution of 1/1000 - 1/1250 and squamous lung carcinoma

 

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