A synthetic peptide corresponding to residues near the C-terminus of human Aldh1a1 was used as an immunogen.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Clone Name
EP1933Y
Isotype
Rabbit IgG
Species Reactivity
Human, Mouse, Rat
Concentration
Purification
Guaranteed Application *
WB, IHC
Suggested Dilutions
WB: 1:2000 IHC: 1:100 250 ICC: 1:100 250 IP: 1:30
Background
This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes. [provided by RefSeq].
Related Pathway
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