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Home Antibody All anti-APH1A antibodies

Anti-APH1A Antibody

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SKU Description Amount Price Availability*  
TA303251 Goat Polyclonal Antibody against APH1A 100ug $325 3-7 Days
LC421466 APH1A HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)

OriGene Data

Immunogen Peptide with sequence C-HVTDRSDARLQYG, from the internal region of the protein sequence according to NP_001071096.1; NP_057106.2.
Clone Name IsotypeGoat IgG
Species ReactivityTest: Human. Expected from seq similarity: Human, Mouse, Rat, Dog, Pig, Cow Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:128,000. WB: 0.05-0.1µg/ml.
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens APH1A gamma secretase subunit (APH1A), transcript variant 1
Alternative Name6530402N02Rik; APH-1; APH-1A; CGI-78
Database LinkNP_001071096
Entrez Gene 51107 Human
Entrez Gene 226548 Mouse
Entrez Gene 365872 Rat
Entrez Gene 483181 Dog
FunctionAPH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM].
Related PathwayES Cell Differentiation/IPSTransmembraneDruggable Genome Notch signaling pathwayAlzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

TA303251 (0.05µg/ml) staining of Human Brain (Cerebral Cortex) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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