Home Antibody All anti-HCST antibodies
Also for HCST (NM_001007469)
| Peptide with sequence C-RSPAQEDGKVYIN, from the C Terminus of the protein sequence according to NP_055081.1; NP_001007470.1.|
|Test: Human. Expected from seq similarity: Human, Mouse, Rat
||ELISA: 1:128,000. WB: 0.2-0.6µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
| Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Homo sapiens hematopoietic cell signal transducer (HCST), transcript variant 2|
|DAP10; KAP10; PIK3AP|
Entrez Gene 10870 Human
Entrez Gene 23900 Mouse
Entrez Gene 474146 Rat
|This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. |
|TransmembraneDruggable Genome Natural killer cell mediated cytotoxicity|
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TA303159 (0.2µg/ml) staining of human spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.