Home Antibody All anti-CTTN antibodies
Also for CTTN (NM_005231)
| Peptide with sequence WKASAGHAVSIA-C, from the N Terminus of the protein sequence according to NP_005222.|
|Test: Mouse. Expected from seq similarity: Human, Mouse, Rat, Dog, Cow
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
| Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Homo sapiens cortactin (CTTN), transcript variant 1|
Entrez Gene 2017 Human
Entrez Gene 13043 Mouse
Entrez Gene 60465 Rat
Entrez Gene 610283 Dog
|This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq]. |
|Druggable Genome Tight junctionPathogenic Escherichia coli infection|
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TA302747 staining (0.5µg/ml) of A431 lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.