Home Antibody All anti-PTPN11 antibodies
Also for PTPN11 (NM_002834)
|Peptide with sequence C-YENVGLMQQQKSFR, from the C Terminus of the protein sequence according to NP_002825.3.|
|Test: Human, Mouse. Expected from seq similarity: Human, Mouse, Rat, Pig, Cow
||ELISA: 1:32,000. WB 1-3µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1|
|BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2|
Entrez Gene 5781 Human
Entrez Gene 19247 Mouse
Entrez Gene 25622 Rat
|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq]. |
|PhosphataseDruggable Genome Jak-STAT signaling pathwayNatural killer cell mediated cytotoxicityLeukocyte transendothelial migrationNeurotrophin signaling pathwayAdipocytokine signaling pathwayEpithelial cell signaling in Helicobacter pylori infectionMore Pathways >> |
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TA302607 staining (2µg/ml) of human muscle lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.