Home Antibody All anti-CILP antibodies
Also for CILP (NM_003613)
|Peptide with sequence C-NYRRTDHEDPRVK, from the internal region of the protein sequence according to NP_003604.2.|
|Test: Rat. Expected from seq similarity: Human, Mouse, Rat, Dog
||ELISA: 1:128,000. WB: 0.1-0.3µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (CILP)|
Entrez Gene 8483 Human
Entrez Gene 214425 Mouse
Entrez Gene 315761 Rat
Entrez Gene 487603 Dog
|Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase, however later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. One isoform of the protein, CILP-1, functions as an IGF-1 antagonist. |
|Secreted ProteinPhosphataseDruggable Genome |
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TA302452 (0.03µg/ml) staining of rat spinal cord lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.