Home Antibody All anti-ALOX5 antibodies
Also for ALOX5 (NM_000698)
|Peptide with sequence C-ERNKKKQLPYYYLSPD, from the C Terminus of the protein sequence according to NP_000689.1.|
|Test: Human, Rat. Expected from seq similarity: Human, Mouse, Rat, Dog
||ELISA: 1:32,000. WB: 0.3-1µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens arachidonate 5-lipoxygenase (ALOX5), transcript variant 1|
|5-LO; 5-LOX; 5LPG; LOG5|
Entrez Gene 240 Human
Entrez Gene 11689 Mouse
Entrez Gene 25290 Rat
Entrez Gene 477753 Dog
|This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq]. |
|Druggable Genome Arachidonic acid metabolismMetabolic pathways|
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TA302414 (0.3µg/ml) staining of Rat Stomach lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.