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Home Antibody All anti-ALOX5 antibodies

Anti-ALOX5 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302414
  • Goat Polyclonal Antibody against Arachidonate 5-lipoxygenase
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400234) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for ALOX5 (NM_000698)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPeptide with sequence C-ERNKKKQLPYYYLSPD, from the C Terminus of the protein sequence according to NP_000689.1.
Clone Name IsotypeGoat IgG
Species ReactivityTest: Human, Rat. Expected from seq similarity: Human, Mouse, Rat, Dog Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:32,000. WB: 0.3-1µg/ml.
Predicted MW Explanation 81614Da
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Reference Data

Target NameHomo sapiens arachidonate 5-lipoxygenase (ALOX5), transcript variant 1
Alternative Name5-LO; 5-LOX; 5LPG; LOG5
Database LinkNP_000689
Entrez Gene 240 Human
Entrez Gene 11689 Mouse
Entrez Gene 25290 Rat
Entrez Gene 477753 Dog
FunctionThis gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq].
Related PathwayDruggable Genome Arachidonic acid metabolismMetabolic pathways

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
TA302414 (0.3µg/ml) staining of Rat Stomach lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

 

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