Home Antibody All anti-ALDH1A1 antibodies
Also for ALDH1A1 (NM_000689)
|Peptide with sequence C-RELGEYGFHEYTE, from the internal region of the protein sequence according to NP_000680.2.|
|Test: Human. Expected from seq similarity: Human, Mouse, Rat
||ELISA: 1:32,000. WB: 1-3µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens aldehyde dehydrogenase 1 family, member A1 (ALDH1A1)|
|ALDC; ALDH-E1; ALDH1; ALDH11; HEL-9; HEL-S-53e; HEL12; PUMB1; RALDH1|
Entrez Gene 216 Human
Entrez Gene 11668 Mouse
Entrez Gene 24188 Rat
|This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes. [provided by RefSeq]. |
|ES Cell Differentiation/IPSDruggable Genome Retinol metabolismMetabolic pathways|
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TA302409 (1µg/ml) staining of Human Liver Lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
HEK293 overexpressing ALDH1A1 and probed with TA302409 (mock transfection in first lane).