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Home Antibody All anti-PXN antibodies

Anti-PXN Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302183
  • Rabbit Polyclonal Antibody against PXN (Center)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401010) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for PXN (NM_002859)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human PXN.
Clone Name IsotypeRabbit Ig
Species ReactivityHuman Concentration0.25 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:50~100; IHC: 1: 10~50; ELISA: 1: 1,000;
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Reference Data

Target NameHomo sapiens paxillin (PXN), transcript variant 1
Alternative NameFLJ16691
Database LinkNP_002850
FunctionPXN is a cytoskeletal adapter protein involved in organisation and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation and cancer. PXN contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk 2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., Actin, Vinculin, Crk).
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
(LEFT) Western blot analysis of PXN (arrow) using rabbit polyclonal PXN Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PXN gene (Lane 2) (Origene Technologies). (RIGHT) Western blot analysis of PXN Antibody (Center) in Y79 cell line lysates (35ug/lane). PXN (arrow) was detected using the purified Pab (1:60 dilution).
IHC Image
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with PXN antibody (Center) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

 

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