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Home Antibody All anti-BCL2L2 antibodies

Anti-BCL2L2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302168
  • Rabbit Polyclonal Antibody against BCL2L2
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401312) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for BCL2L2 (NM_004050)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis antibody was developed against a synthetic peptide corresponding within amino acid residues 1-100 of human Bcl-W.
Clone Name IsotypeRabbit Ig
Species ReactivityHuman, Mouse Concentration0.25 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 100~500; IHC: 1:50~100; ELISA: 1: 1,000;
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Reference Data

Target NameHomo sapiens BCL2-like 2 (BCL2L2), transcript variant 1
Alternative NameBCL-W; BCL2-L-2; BCLW; PPP1R51
Database LinkNP_004041
FunctionBcl-w is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.
Related Pathway
Apoptosis

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WB Image
(LEFT)Western blot analysis of anti-Bcl-w BH3 domain Pab in HL-60 cell lysate. Bcl-w BH3 domain (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. (RIGHT)Western blot analysis of Bcl-w3 (arrow) using rabbit polyclonal Bcl-w BH3 Domain Antibody . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the BCL2L2 gene (Lane 2) (Origene Technologies).
IHC Image
(TOP)Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. (BUTTOM)Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with Bcl-w BH3 Domain Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

 

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