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Home Antibody All anti-UBQLN1 antibodies

Anti-UBQLN1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302118
  • Rabbit Polyclonal Antibody against UBQLN1 (N-term)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402265) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for UBQLN1 (NM_013438)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human Ubiquilin1.
Clone Name IsotypeRabbit Ig
Species ReactivityHuman, Mouse Concentration0.25 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1: 100~500; ELISA: 1: 1,000;
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Reference Data

Target NameHomo sapiens ubiquilin 1 (UBQLN1), transcript variant 1
Alternative NameDA41; DSK2; PLIC-1; UBQN; XDRP1
Database LinkNP_038466
FunctionUbiquilin 1 (UBQLN1), also known as DA41, was isolated from an adult rat lung cDNA library, and encodes a cellular protein that associates with DAN.1 DAN expression is reduced in rat fibroblast 3Y1 cells transformed with mouse sarcoma virus and in rodent fibroblasts transformed with a variety of oncogenes. The DAN-DA41 interaction is mediated through the N-terminal domain and a cysteine-knot region of DAN. Human DA41 encodes a 589-amino acid protein with 86% amino acid sequence identity with rat protein.2 DA41 expression is regulated in a cell cycle-dependent manner. PLIC1 and PLIC2 (UBQLN2) are homologs of the mouse Plics (proteins linking integrin-associated protein (IAP) and cytoskeleton) and the yeast Dsk2 protein. PLIC1, also called UBQLN1, shares 72% amino acid identity with PLIC2,3 Two motifs are conserved in the mammalian PLICs and yeast Dsk2, an N-terminal ubiquitin-like (UBL) domain and a C-terminal ubiquitin-associated (UBA) domain. Unlike ubiquitin, the UBL domain of the PLICs does not have a diglycine motif in its C terminus. The UBA domain is present in multiple enzyme classes of the ubiquitination machinery. Human PLICs associate with both proteasomes and ubiquitin ligases in large complexes. Overexpression of PLICs impairs the in vivo degradation of 2 unrelated ubiquitin-dependent proteasome substrates, p53 and I-kappa-B-alpha (NFKBIA), but not a ubiquitin-independent substrate. PLICs may link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. The DA41 gene maps to chromosome 9q21.2-q21.3, a position overlapping a candidate tumor suppressor locus for bladder cancer.2
Related Pathway

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WB Image
(LEFT)The anti-Ubiquilin1 Pab is used in Western blot to detect Ubiquilin1 in mouse cerebellum tissue lysate. (RIGHT)Western blot analysis of Ubiquilin1 (arrow) using Ubiquilin1 Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Ubiquilin1 gene (Lane 2) (Origene Technologies).

 

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