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Home Antibody All anti-FGFR1 antibodies

Anti-FGFR1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302062
  • Rabbit Polyclonal Antibody against FGFR1 (Y653)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402963) , 20ug Explanation
100ug 325 In Stock
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WB(1)
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Also for FGFR1 (NM_023110)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 631-660 amino acids from human FGFR1.
Clone Name IsotypeRabbit Ig
Species ReactivityHuman (Predicted: Mouse, Rat, Zebrafish, Chicken, Xenopus) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000
Predicted MW Explanation 91867 Da
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.

Reference Data

Target NameHomo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 1
Alternative NamebFGF-R-1; BFGFR; CD331; CEK; FGFBR; FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD
Database LinkNP_075598
Entrez Gene 2260 Human
Entrez Gene 14182 Mouse
Entrez Gene 79114 Rat
FunctionFGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome.
Related PathwayProtein KinaseTransmembraneDruggable Genome MAPK signaling pathwayAdherens junctionRegulation of actin cytoskeletonPathways in cancerProstate cancerMelanomaMore Pathways >>

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WB Image
Western blot analysis of FGFR1 (arrow) using rabbit polyclonal FGFR1 Antibody (Y653) (RB11303). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR1 gene (Lane 2) (Origene Technologies).

 

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