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Home Antibody All anti-APOE antibodies

Anti-APOE Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302010
  • Rabbit Polyclonal Antibody against APOE (C-term)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424959) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for APOE (NM_000041)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis APOE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human APOE.
Clone Name IsotypeRabbit Ig
Species ReactivityHuman (Predicted: Monkey, Rabbit) Concentration0.25 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000, IHC: 1:10~50
Predicted MW Explanation 36154 Da
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Reference Data

Target NameHomo sapiens apolipoprotein E (APOE)
Alternative NameAD2; LDLCQ5; LPG
Database LinkNP_000032
Entrez Gene 348 Human
Entrez Gene 714623 Monkey
FunctionChylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III),in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Related PathwaySecreted ProteinStem cell - PluripotencyAdult stem cellsDruggable Genome Alzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of lysate from human blood plasma tissue lysate, using APOE Antibody (C-term)(Cat. #TA302010). TA302010 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
IHC Image
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with APOE antibody (C-term) (Cat.#TA302010), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

 

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