Home Antibody All anti-BMI1 antibodies
Also for BMI1 (NM_005180)
|A synthetic peptide made to an internal region (within residues 1-100) of the human Bmi1 protein. [Swiss-Prot# P35226]|
||WB: 0.5-2 ug/ml
|Tris-glycine, 150mM NaCl and 0.05% sodium azide|
|Immunogen affinity purified
|Homo sapiens BMI1 proto-oncogene, polycomb ring finger (BMI1)|
|FLVI2/BMI1; PCGF4; RNF51|
Entrez Gene 648 Human
Entrez Gene 12151 Mouse
|The Bmi1 oncogene has been shown to induce telomerase activity and immortalize human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi1 is also important in maintaining stem cells' ability to self renew. It has also been termed an oncogene with aberrant expression in various carcinomas. It has been shown to be a negative regulator of p19Arf, Ink4a (p14Arf) and tp53 known tumor repressors. Ablation of Bmi1 is required for short term survival of cancer cells.|
|ES Cell Differentiation/IPSTranscription FactorsDruggable Genome |
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Detection of Bmi1 protein in skeletal muscle
Immunocytochemistry/Immunofluorescence: BMI1 antibody was tested in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).