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Home Antibody All anti-PIK3C3 antibodies

Anti-PIK3C3 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA301456 Rabbit Polyclonal Antibody against VPS34 100ul $325 2 Weeks
LC400941 PIK3C3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for PIK3C3 (NM_002647)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenSynthetic peptide made to an internal portion of the human protein (within residues 700-850). [Swiss-Prot# Q8NEB9]
Clone Name IsotypeIgG
Species Reactivityhuman, rat, mouse, porcine ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1: 1000
BufferPBS, 0.1% BSA, 50% glycerol and 0.05% Sodium Azide
Purification peptide affinity purified

Reference Data

Target NameHomo sapiens phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3), transcript variant 1
Alternative NamehVps34; Vps34; VPS34
Database LinkNP_002638
Entrez Gene 5289 Human
Entrez Gene 225326 Mouse
Entrez Gene 65052 Rat
FunctionVPS34, also known as phosphoinositide-3-kinase p100 subunit or PIK3C3 (phosphoinositide-3-kinase, class III), is a member of the PI3/PI4-kinase family. It is ubiquitously expressed with predominant expression in skeletal muscle and is believed to participate in endosome to lysosome transport, multivesicular body formation, autophagy and retrograde endosome to Golgi transport. VPS34 is the catalytic subunit of class III PI3Ks and forms a heterodimer with p150, a regulatory subunit of class 3 PI3Ks. It exclusively phosphorylates phosphatidylinositol to produce PtdIns3P. The activity of VPS34 is enhanced by manganese and can be regulated by nutrients, suggesting an important role of VPS34 in the regulation of mTOR protein synthesis. VPS34 also forms a complex with Beclin1 that promotes autophagy and tumor supression.
Related PathwayDruggable Genome Inositol phosphate metabolismMetabolic pathwaysPhosphatidylinositol signaling systemRegulation of autophagy

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WB Image
Detection of VPS34 in HepG2 whole cell lysates


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