Home Antibody All anti-HMGB1 antibodies
Also for HMGB1 (NM_002128)
|A synthetic peptide made to an internal portion of the human HMGB1 protein sequence (between residues 100-200). [UniProt #P09429]|
|human, mouse, rat, dog, Chinese hamster, bovine
||0.5~1.0 mg/ml (Lot Dependent)
|WB, IHC, IF
||WB: 0.5-1.0 ug/ml
|Tris-glycine, 150mM NaCl and 0.1% sodium azide|
|Affinity purified (Protein A or G Sepharose)
|Homo sapiens high mobility group box 1 (HMGB1)|
|HMG1; HMG3; SBP-1|
|HMGB1 and HMGB2 are part of the chromatin non-histone high mobility group proteins 1 and 2. These proteins (containing multiple HMG-boxes) are conserved domains of 80 amino acids which mediate the DNA binding of many proteins. HMG box domains recognize DNA structure. Both HMGB1 and HMGB2 contain an N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of these proteins contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMGB1 and HMGB2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites. They may also serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription, and replication.|
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Detection of HMGB1 in whole cell HeLa lysate. ECL exposure, 1 min
Immunocytochemistry/Immunofluorescence: Detection of HMGB1 (Green) in Hela cells using HMGB1 Antibody. Nuclei (Blue) are counterstained with Hoecsht 33258.