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Home Antibody All anti-HMGB1 antibodies

Anti-HMGB1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301448
  • Rabbit Polyclonal Antibody against HMGB1 - Oligodendrocyte Marker
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400775) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)
IF(1)
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Also for HMGB1 (NM_002128)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide made to an internal portion of the human HMGB1 protein sequence (between residues 100-200). [UniProt #P09429]
Clone Name IsotypeIgG
Species Reactivityhuman, mouse, rat, dog, Chinese hamster, bovine ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 0.5-1.0 ug/ml
BufferTris-glycine, 150mM NaCl and 0.1% sodium azide
Purification Affinity purified

Reference Data

Target NameHomo sapiens high mobility group box 1 (HMGB1)
Alternative NameHMG1; HMG3; SBP-1
Database LinkNP_002119
Entrez Gene 3146 Human
Entrez Gene 15289 Mouse
Entrez Gene 25459 Rat
Entrez Gene 403170 Dog
FunctionHMGB1 and HMGB2 are part of the chromatin non-histone high mobility group proteins 1 and 2. These proteins (containing multiple HMG-boxes) are conserved domains of 80 amino acids which mediate the DNA binding of many proteins. HMG box domains recognize DNA structure. Both HMGB1 and HMGB2 contain an N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of these proteins contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMGB1 and HMGB2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites. They may also serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription, and replication.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Detection of HMGB1 in whole cell HeLa lysate. ECL exposure, 1 min
IHC Image
Staining of HMGB1 in mouse liver
IF Image
Immunocytochemistry/Immunofluorescence: Detection of HMGB1 (Green) in Hela cells using HMGB1 Antibody. Nuclei (Blue) are counterstained with Hoecsht 33258.

 

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