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Home Antibody All anti-APEX1 antibodies

Anti-APEX1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301441
  • Rabbit Polyclonal Antibody against APE1
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400618) , 20ug
100ul 325 In Stock
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WB(2)
IHC(1)
IF(1)
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Also for APEX1 (NM_001641)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenAffinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein.
Clone Name IsotypeIgG
Species Reactivityhuman, mouse, rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1: 1000
BufferTris-glycine, 150mM NaCl and 0.05% sodium azide
Purification Affinity purified

Reference Data

Target NameHomo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1
Alternative NameAPE; APE1; APEN; APEX; APX; HAP1; REF1
Database LinkNP_001632
FunctionThe mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme has been shown to function as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1a as well as other transcription factors. Recently, APE has also been shown to control p53 activity through redox alteration. APE is also linked to apoptosis, associated with thioredoxin, and altered levels of APE have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.
Related Pathway

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WB Image
Western Blot: APE1 Antibody TA301441 - Analysis of APE1 in cell lysates: 1. HeLa, 2. Ntera2, 3. A431, 4. HepG2, 5. MCF7, 6. NIH 3T3, 7. PC12, and 8. Cos 7.
WB Image
Western Blot: APE1 Antibody TA301441 - SH-SY5Y (nuclear extract) tested at 1:1000 dilution. Image provided by verified customer review.
IHC Image
Immunohistochemistry: APE1 Antibody TA301441 - Immunohistochemical staining of APE-ref-1 in prostate cancer.
IF Image
Immunocytochemistry/Immunofluorescence: APE1 Antibody TA301441 - Detection of APE1 (Green) in HepG2 cells using NB100-101. Nuclei (Blue) are counterstained with Hoechst 33258.

 

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