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Also for APEX1 (NM_001641)
|Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein.|
|human, mouse, rat
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||WB: 1: 1000
|Tris-glycine, 150mM NaCl and 0.05% sodium azide|
|Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1|
|APE; APE1; APEN; APEX; APX; HAP1; REF1|
Entrez Gene 328 Human
Entrez Gene 11792 Mouse
Entrez Gene 79116 Rat
|The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme has been shown to function as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1a as well as other transcription factors. Recently, APE has also been shown to control p53 activity through redox alteration. APE is also linked to apoptosis, associated with thioredoxin, and altered levels of APE have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.|
|Stem cell - PluripotencyTranscription FactorsDruggable Genome Base excision repair|
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Western Blot: APE1 Antibody TA301441 - Analysis of APE1 in cell lysates: 1. HeLa, 2. Ntera2, 3. A431, 4. HepG2, 5. MCF7, 6. NIH 3T3, 7. PC12, and 8. Cos 7.
Western Blot: APE1 Antibody TA301441 - SH-SY5Y (nuclear extract) tested at 1:1000 dilution. Image provided by verified customer review.
Immunohistochemistry: APE1 Antibody TA301441 - Immunohistochemical staining of APE-ref-1 in prostate cancer.
Immunocytochemistry/Immunofluorescence: APE1 Antibody TA301441 - Detection of APE1 (Green) in HepG2 cells using NB100-101. Nuclei (Blue) are counterstained with Hoechst 33258.