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Home Antibody All anti-PRKAR2B antibodies

Anti-PRKAR2B Antibody EP2648

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301360
  • Rabbit Monoclonal Antibody against PRKAR2B (Clone EP2648)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419138) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for PRKAR2B (NM_002736)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human PKA, RIIb was used as an immunogen.
Clone NameEP2648 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsIHC-Fr: Use at an assay dependent concentration; WB: 1:5000 - 1:20000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250; FC: 1:20
Predicted MW Explanation 46 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens protein kinase, cAMP-dependent, regulatory, type II, beta (PRKAR2B)
Alternative NamePRKAR2; RII-BETA
Database LinkNP_002727
Entrez Gene 5577 Human
Entrez Gene 19088 Mouse
Entrez Gene 24679 Rat
FunctioncAMP-dependent protein kinase (PKA) mediates cyclic AMP, an important second messenger in the coordinated regulation of cellular metabolism. PKA is assembled from two regulatory and two catalytic subunits. The RII beta (RIIb) regulatory isoform is abundant in brown and white adipose tissue and brain, with limited expression elsewhere. RIIb is demonstrated to play a role in regulating energy balance and adiposity, thus making it a potential target for therapeutic intervention in obesity (1, 2). It has been shown that RIIb is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. This suggests that the RIIb cAMP receptor, by binding to its ligand, cAMP, acts as a tumor suppressor protein exerting growth inhibition, differentiation, and reverse transformation (3).
Related PathwayDruggable Genome ApoptosisInsulin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PKA 2 beta (regulatory subunit) antibody [EP2648]; All lanes : Anti-PKA 2 beta (regulatory subunit) antibody [EP2648] at 1/20000 dilution.Lane 1 : Fetal brain lysate.Lane 2 : Human testis lysate.Lane 3 : NIH/3T3 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 46 kDa.Observed band size : 46 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PKA 2 beta (regulatory subunit) antibody [EP2648]; TA301360, at 1/100 dilution, staining PKA 2 beta (regulatory subunit) in paraffin-embedded human brain tissue by Immunohistochemistry.

 

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