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Anti-PRKAR2B Antibody EP2648
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Also for PRKAR2B (NM_002736)
|A synthetic peptide corresponding to residues near the N-terminus of human PKA, RIIb was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||IHC-Fr: Use at an assay dependent concentration; WB: 1:5000 - 1:20000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250; FC: 1:20
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for IP.
|Homo sapiens protein kinase, cAMP-dependent, regulatory, type II, beta (PRKAR2B)|
Entrez Gene 5577 Human
Entrez Gene 19088 Mouse
Entrez Gene 24679 Rat
|cAMP-dependent protein kinase (PKA) mediates cyclic AMP, an important second messenger in the coordinated regulation of cellular metabolism. PKA is assembled from two regulatory and two catalytic subunits. The RII beta (RIIb) regulatory isoform is abundant in brown and white adipose tissue and brain, with limited expression elsewhere. RIIb is demonstrated to play a role in regulating energy balance and adiposity, thus making it a potential target for therapeutic intervention in obesity (1, 2). It has been shown that RIIb is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. This suggests that the RIIb cAMP receptor, by binding to its ligand, cAMP, acts as a tumor suppressor protein exerting growth inhibition, differentiation, and reverse transformation (3). |
|Druggable Genome ApoptosisInsulin signaling pathway|
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Western blot - PKA 2 beta (regulatory subunit) antibody [EP2648]; All lanes : Anti-PKA 2 beta (regulatory subunit) antibody [EP2648] at 1/20000 dilution.Lane 1 : Fetal brain lysate.Lane 2 : Human testis lysate.Lane 3 : NIH/3T3 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 46 kDa.Observed band size : 46 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PKA 2 beta (regulatory subunit) antibody [EP2648]; TA301360, at 1/100 dilution, staining PKA 2 beta (regulatory subunit) in paraffin-embedded human brain tissue by Immunohistochemistry.