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Anti-TP53 Antibody EPR358(2)
Also for TP53 (NM_000546)
|A synthetic acetylated peptide corresponding to residues surrounding K382 of human p53 was used as an immunogen. The antibody only detects p53 acetylated on Lysine 382.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:250 - 1:5000; ICC: 1:100
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens tumor protein p53 (TP53), transcript variant 1|
|BCC7; LFS1; P53; TRP53|
|p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers. p53 is acetylated at lysine 382 upon Ras expression, an event that is essential for its biological function (4). Acetylation at lysine 382 specifically determines the PAb421 epitope (5). |
Delta-Notch Signaling Pathway
MAPK signaling pathway
Senescence and Autophagy
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot - p53 (acetyl K382) antibody [EPR358(2)]; All lanes : Anti-p53 (acetyl K382) antibody [EPR358(2)] at 1/5000 dilution.Lane 1 : HepG2 cell lysates un-treated.Lane 2 : HepG2 cell lysates treated with etopside and TSA.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 53 kDa.Observed band size : 53 kDa.