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Home Antibody All anti-CTNNB1 antibodies

Anti-CTNNB1 PHOSPHO Antibody EP742(2)Y


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SKU Description Amount Price Availability*  
TA301246 Rabbit Monoclonal Antibody against CTNNB1 (Clone EP742(2)Y) (Phospho-specific) 100ul $325 In Stock
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OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding threonine 33 and 37 of human Beta-catenin was used as an immunogen. This antibody detects Beta-catenin phosphorylated on threonine 33 and/or 37.
Clone NameEP742(2)Y IsotypeIgG
Species ReactivityRat, Human (Does not react with: Mouse) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 1
Alternative Namearmadillo; CTNNB; MRD19
Database LinkNP_001895
Entrez Gene 1499 Human
Entrez Gene 84353 Rat
FunctionBeta-catenin is a key regulatory protein involved in cell adhesion and signal transduction through the Wnt pathway, and plays important roles in development, cellular proliferation, and differentiation (1). Beta-catenin is phosphorylated at four serine and threonine residues at the N-terminus (Ser33, Ser45, Ser37 and Thr41). Ser45 is phosphorylated by CK1, and is thought to be a priming site for the phosphorylation by glycogen synthase kinase-3 (GSK-3) (2). Wnt signaling antagonizes the action of GSK-3, which in subsequent phosphorylation steps, leads to its degradation (3). Mutations in the Beta-catenin gene, have been implicated in its accumulation and various forms of carcinomas (4).
Related PathwayES Cell Differentiation/IPSTranscription FactorsDruggable Genome Wnt signaling pathwayFocal adhesionAdherens junctionTight junctionLeukocyte transendothelial migrationMelanogenesisMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - beta Catenin (phospho T33 + T37) antibody [EP742(2)Y]; All lanes : Anti-beta Catenin (phospho S33 + S37) antibody [EP742(2)Y] at 1/500 dilution.Lane 1 : 293T cell lysates, untreated.Lane 2 : 293T cell lysates, treated with calyculin A.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 86 kDa.Observed band size : 86 kDa.


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