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Home Antibody All anti-CHGA antibodies

Anti-CHGA Antibody EP1030Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301203
  • Rabbit Monoclonal Antibody against CHGA (Clone EP1030Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400511) , 20ug
100ul $325 3-7 Days
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WB(1)
IHC(1)
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Also for CHGA (NM_001275)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human Chromogranin A was used as an immunogen.
Clone NameEP1030Y IsotypeIgG
Species ReactivityHuman, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 10,000; IHC: 1: 100~250; ICC: 1: 100~250; FC: 1:20
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens chromogranin A (parathyroid secretory protein 1) (CHGA)
Alternative NameCGA
Database LinkNP_001266
FunctionChromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neuroendocrine cells. CgA is believed to play a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathways and inhibit hormone and neurotransmitter release (1). Also, the widespread distribution of CgA has made the measurement of circulating immunoreactive CgA a valuable tool in the diagnosis of neuroendocrine neoplasia, and CgA immunohistochemistry can help to identify the neuroendocrine nature of tumors. The N-terminal domain of CgA inhibits tumor necrosis factor ? (TNF?) induced gap formation in human umbilical venous endothelial cells (2). CgA levels which reflect neuroendocrine differentiation of prostatic carcinoma may have a diagnostic, therapeutic and prognostic role in the management of prostate cancer patients (3).
Related Pathway

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WB Image
Western blot - Chromogranin A antibody [EP1030Y]; Anti-Chromogranin A antibody [EP1030Y] + SH-SY5Y cell lysate at 10 µg.Secondary.HRP conjugated Goat anti-rabbit at 1/2000 dilution.Predicted band size : 51 kDa.Observed band size : 90 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Chromogranin A antibody [EP1030Y]; Human pancreas tissue stained with TA301203 at 1/100 dilution.

 

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