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Home Antibody All anti-GSK3A antibodies

Anti-GSK3A PHOSPHO Antibody EPR933Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301166
  • Rabbit Monoclonal Antibody against GSK3A (Clone EPR933Y) (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for GSK3A (NM_019884)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 279 in human GSK3a and tyrosine 216 in human GSKb was used as an immunogen. This antibody detects both GSK? phosphorylated on tyrosine 279 and GSK3? phosphorylyated on tyrosine 216.
Clone NameEPR933Y IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500~2000; IHC: 1: 100; ICC: 1:250; IP: 1:40
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens glycogen synthase kinase 3 alpha (GSK3A)
Alternative NameDKFZp686D0638
Database LinkNP_063937
FunctionGlycogen synthases kinase 3 alpha (GSK3-?) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-? activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-? by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-? activitiy has been linked to a pathogenic mechanism in Alzheimer's disease (4). GSK3 beta) plays a key role in insulin and Wnt signaling, phosphorylating downstream targets by default, and becoming inhibited following the extracellular signaling event (5).
Related Pathway

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WB Image
Western blot - GSK3 (alpha + beta) (phospho Y279 + Y216) antibody [EPR933Y]; All lanes : Anti-GSK3 (alpha + beta) (phospho Y279 + Y216) antibody [EPR933Y] at 1/2000 dilution.Lane 1 : 293 cell lysate, cells untreated.Lane 2 : 293 cell lysate, cells treated with AP.Lysates/proteins at 10 µg per lane.Secondary.HRP conjugated Goat anti-rabbit at 1/2000 dilution.Predicted band size : 51 , 47 kDa.Observed band size : 47-52 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GSK3 (alpha + beta) (phospho Y279 + Y216) antibody [EPR933Y]; Human brain tissue stained with TA301166 at 1/100 dilution.

 

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