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Anti-FCGR2B PHOSPHO Antibody EP926Y
Also for FCGR2B (NM_004001)
|A phospho specific peptide corresponding to residues surrounding tyrosine 292 of human Fc gamma RIIb. This antibody detects Fc gamma RIIb phosphorylated on tyrosine 292.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:50000 - 1:100000; IP: 1:70
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
|Homo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B), transcript variant 1|
|CD32; CD32B; FCG2; FCGR2; IGFR2|
Entrez Gene 2213 Human
|Low affinity IgG Fc receptor gamma II (Fc-gamma II), also known as CD32, is a member of the immunoreceptor tyrosine-based activating/inhibitory motif (ITAM/ITIM) family. Fc gamma receptors play a critical role in immunity by linking the IgG antibody mediated response with the regulatory functions of the immune system (1). Three classes of Fc gamma receptor exist; Fc gamma RI (CD64, a high affinity receptor), Fc gamma RII, and RIII (CD32 and CD16 respectively, both low affinity receptors). Fc gamma RIIa is an activating receptor, while RIIb1, RIIb2, and RIIb3 are inhibitory receptors generated by alternative splicing (1-2). Fc gamma RIIa is critical for antigen-presenting-cell activation and Fc gamma RIIb downregulates B-cell functions (3). Coligation of FcgammaRIIb with the B-cell antigen receptor (BCR) results in the abrogation of B-cell activation and become phosphorlyated by protein tyrosine kinase (PTK) (4) |
|ES Cell Differentiation/IPSTransmembrane B cell receptor signaling pathwayFc gamma R-mediated phagocytosisSystemic lupus erythematosus|
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Western blot - CD32 (phospho Y292) antibody [EP926Y]; All lanes : Anti-CD32 (phospho Y292) antibody [EP926Y] at 1/100000 dilution.Lane 1 : Untreated Daudi cell lysate .Lane 2 : Pervanadate-treated Daudi cell lysate .Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti-Rabbit antibody at 1/2000 dilution.Predicted band size : 40,44 kDa.