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Home Antibody All anti-FCGR2B antibodies

Anti-FCGR2B PHOSPHO Antibody EP926Y

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SKU Description Amount Price Availability*  
TA301165 Rabbit Monoclonal Antibody against FCGR2B (Clone EP926Y) (Phospho-specific) 100ul $325 In Stock
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WB(1)

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 292 of human Fc gamma RIIb. This antibody detects Fc gamma RIIb phosphorylated on tyrosine 292.
Clone NameEP926Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:50000 - 1:100000; IP: 1:70
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC/IF or IHC-P.

Reference Data

Target NameHomo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B), transcript variant 1
Alternative NameCD32; CD32B; FCG2; FCGR2; IGFR2
Database LinkNP_003992
Entrez Gene 2213 Human
FunctionLow affinity IgG Fc receptor gamma II (Fc-gamma II), also known as CD32, is a member of the immunoreceptor tyrosine-based activating/inhibitory motif (ITAM/ITIM) family. Fc gamma receptors play a critical role in immunity by linking the IgG antibody mediated response with the regulatory functions of the immune system (1). Three classes of Fc gamma receptor exist; Fc gamma RI (CD64, a high affinity receptor), Fc gamma RII, and RIII (CD32 and CD16 respectively, both low affinity receptors). Fc gamma RIIa is an activating receptor, while RIIb1, RIIb2, and RIIb3 are inhibitory receptors generated by alternative splicing (1-2). Fc gamma RIIa is critical for antigen-presenting-cell activation and Fc gamma RIIb downregulates B-cell functions (3). Coligation of FcgammaRIIb with the B-cell antigen receptor (BCR) results in the abrogation of B-cell activation and become phosphorlyated by protein tyrosine kinase (PTK) (4)
Related PathwayES Cell Differentiation/IPSTransmembrane B cell receptor signaling pathwayFc gamma R-mediated phagocytosisSystemic lupus erythematosus

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - CD32 (phospho Y292) antibody [EP926Y]; All lanes : Anti-CD32 (phospho Y292) antibody [EP926Y] at 1/100000 dilution.Lane 1 : Untreated Daudi cell lysate .Lane 2 : Pervanadate-treated Daudi cell lysate .Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti-Rabbit antibody at 1/2000 dilution.Predicted band size : 40,44 kDa.
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