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Home Antibody All anti-TP53 antibodies

Anti-TP53 PHOSPHO Antibody EP2393Y

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SKU Description Amount Price Availability*  
TA301124
  • Rabbit Monoclonal Antibody against TP53 (Clone EP2393Y) (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
IF(1)
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Also for TP53 (NM_000546)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding serine 33 of human p53 was used as an immunogen. This antibody detects p53 phosphorlyated at serine 53.
Clone NameEP2393Y IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:2000; ICC/IF: 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens tumor protein p53 (TP53), transcript variant 1
Alternative NameBCC7; LFS1; P53; TRP53
Database LinkNP_000537
Entrez Gene 7157 Human
Functionp53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers (4,5). Cyclin dependent kinase 9, whose well-known substrate is RNA polymerase II, can also phosphorylate p53, more specifically, Ser33 on the N-terminus and, Ser315 and Ser392 on the C-terminus (6).
Related PathwayStem cell - PluripotencyTranscription FactorsDruggable Genome MAPK signaling pathwayCell cyclep53 signaling pathwayApoptosisWnt signaling pathwayNeurotrophin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - p53 (phospho S33) antibody [EP2393Y]; All lanes : Anti-p53 (phospho S33) antibody [EP2393Y] at 1/2000 dilution.Lane 1 : T47D cell lysates, untreated.Lane 2 : T47D cell lysates, treated with etoposide.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 53 kDa.Observed band size : 53 kDa.
IF Image
Immunocytochemistry/ Immunofluorescence - p53 (phospho S33) antibody [EP2393Y]; TA301124 at 1/100 dilution staining phosphorylated p53 in A431 cells by Immunofluorescence.

 

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