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Home Antibody All anti-MAP2K1 antibodies

Anti-MAP2K1 Antibody EPR2365Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301098
  • Rabbit Monoclonal Antibody against MAP2K1 (Clone EPR2365Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400974) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for MAP2K1 (NM_002755)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding threonine 292 of human MEK1 was used as an immunogen.
Clone NameEPR2365Y IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:500
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1)
Alternative NameCFC3; MAPKK1; MEK1; MKK1; PRKMK1
Database LinkNP_002746
FunctionMEK1 and MEK2 (MAPK kinase 1/2, or ERK kinase 1/2) are mitogen-activated protein kinases that stimulate MAP kinase (MAPK) activity, playing a role in both cell growth and differentiation (1,2). MEK itself is activated via phosphorylation at serines 217/218 and 221/222 by upstream activator kinases, including c-raf, mos and MEK kinase (3,4). MEK1 and MEK2 are activated by a wide variety of growth factors and cytokines, and also by membrane depolarization and calcium influx (5). Activated MEK1 acts as a dual specificity kinase and phosphorylates both a threonine and a tyrosine residue on MAPK. In return, there is a feedback phosphorylation on MEK1 by MAPK on threonine 292 and 386.
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion
MAPK signaling pathway
Melanogenesis
Senescence and Autophagy
Toll-like receptor signaling pathway

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WB Image
Western blot - MEK1 ( T292) antibody [EPR2365Y]; All lanes : Anti-MEK1 (phospho T292) antibody [EPR2365Y] at 1/500 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HeLa cell lysate, treated with Nocodazole.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit-HRP at 1/1000 dilution.developed using the ECL technique.Predicted band size : 43 kDa.Observed band size : 43 kDa.

 

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