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Home Antibody All anti-RBL2 antibodies

Anti-RBL2 Antibody EP2126Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301091
  • Rabbit Monoclonal Antibody against RBL2 (Clone EP2126Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC417191) , 20ug
100ul $325 3-7 Days
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WB(1)
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Also for RBL2 (NM_005611)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding Serine 672 of human Rb2/p130 was used as an immunogen.
Clone NameEP2126Y IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:5000 - 1:10000; IP: 1:20
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IHC-P.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens retinoblastoma-like 2 (RBL2)
Alternative NameP130; Rb2
Database LinkNP_005602
Functionp130 is a tumor suppressor of the pocket protein family whose expression is posttranscriptionally regulated and largely G0 restricted. The mechanism of down-regulation of p130 expression in proliferating cells was investigated and results indicate that the decline of p130 expression as G0 cells reenter the cell cycle is due to a decrease in protein stability. In vitro polyubiquitination of p130 by SCF(Skp2) was specifically dependent on phosphorylation of p130 on Serine 672 (1). The retinoblastoma family of proteins including pRB, p107 and p130 undergoes cell cycle dependent phosphorylation during the mid-G1 to S phase transition. This phosphorylation is dependent upon the activity of cyclin D/cdk4. In contrast to pRB and p107, p130 is phosphorylated during G0 and the early G1 phase of the cell cycle. Also it is thought that p130, forming a complex with Rad50 through RINT-1, blocks telomerase-independent telomere lengthening in normal cells. Data indicates complementary roles for the Rb/E2F pathway in the control of telomere length (3).
Related Pathway
Adipogenesis
Cell cycle
TGF Beta Signaling Pathway

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WB Image
Western blot - p130 (phospho S672) antibody [EP2126Y]; All lanes : Anti-p130 (phospho S672) antibody [EP2126Y] at 1/10000 dilution.Lane 1 : Jurkat cell lysates, treated with AP.Lane 2 : Jurkat cell lysates, untreated.Lysates/proteins at 10 µg/ml per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 128 kDa.Observed band size : 128 kDa.

 

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