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Anti-PTPN11 Phospho Antibody EP508(2)Y
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Also for PTPN11 (NM_002834)
|A phospho specific peptide corresponding to residues surrounding Tyrosine 542 of human SHP-2 was used as an immunogen. This antibody detects SHP-2 phosphorylated at Tyrosine 542.|
||WB: 1:50,000; ICC: 1: 100; IP: 1:40
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1|
|BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2|
|SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Overexpression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5). |
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
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Western blot analysis on NIH/3T3 cell lysates using anti-Phospho-SHP-2 (pY542), 1:50,000 dilution. Cells were either (A) untreated or (B) treated with PDGF