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Anti-PTPN11 PHOSPHO Antibody EP509Y
Also for PTPN11 (NM_002834)
|A phospho specific peptide corresponding to residues surrounding Tyrosine 582 of human SHP-2. This antibody detects SHP-2 phosphorylated at Tyrosine 582.|
||Lot dependent; please refer to CoA along with shipment
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1|
|BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2|
|SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Overexpression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5). |
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
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Western blot - SHP2 (phospho Y582) antibody [EP509Y]; All lanes : Anti-SHP2 (phospho Y582) antibody [EP509Y] at 1/50000 dilution.Lane 1 : Jurkat cell lysate (untreated).Lane 2 : Jurkat cell lysate (treated with pervanadate).Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP conjugate at 1/2000 dilution.Predicted band size : 68 kDa.Observed band size : 68 kDa.