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Home Antibody All anti-MAPK10 antibodies

Anti-MAPK10 Antibody EP1597Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301031
  • Rabbit Monoclonal Antibody against MAPK10 (Clone EP1597Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403373) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for MAPK10 (NM_138982)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding tyrosine 223 of human JNK3 was used as immunogen. The antibody will detect JNK1 (pY185)/JNK2(pY185)/JNK3 (pY223) phospholyation sites.
Clone NameEP1597Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:5000 - 1:20000; IP: 1:20
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC/IF or IHC-P.

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase 10 (MAPK10), transcript variant 2
Alternative NameJNK3; JNK3A; p493F12; p54bSAPK; PRKM10; SAPK1b
Database LinkNP_620448
Entrez Gene 5602 Human
Entrez Gene 26414 Mouse
Entrez Gene 25272 Rat
FunctionC-Jun N-terminal kinases (JNK) are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group consists of three isoforms (JNK1, 2, and 3) and regulates transcription activity of the AP-1 complex, and release and regulation of cytochome c (1). JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 (2). Unlike other JNK isoforms, JNK3 is only expressed in heart and nervous system nervous. JNK3 has been implicated in stress-induced neuronal apoptosis (3).
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayErbB signaling pathwayWnt signaling pathwayFocal adhesionToll-like receptor signaling pathwayNOD-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - JNK1+JNK2+JNK3 (phospho Y185 + Y185 + Y223) antibody [EP1597Y]; All lanes : Anti-JNK1+JNK2+JNK3 (phospho Y185 + Y185 + Y223) antibody [EP1597Y] at 1/20000 dilution.Lane 1 : lysates from untreated Hek293 cells.Lane 2 : lysates from Hek293 cells treated with UV.Lysates/proteins at 10 ug per lane.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 48 kDa.Observed band size : 48 kDa.

 

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