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Home Antibody All anti-NTRK2 antibodies

Anti-NTRK2 PHOSPHO Antibody EP1298Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301025
  • Rabbit Monoclonal Antibody against NTRK2 (Clone EP1298Y) (Phospho-specific)
100ul 325 In Stock
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IHC(2)
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Also for NTRK2 (NM_006180)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Tyrosine 817 of human TrkB was used as an immunogen. This antibody detects TrkB phosphorylated at Y817.
Clone NameEP1298Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *IHC Suggested DilutionsWB: 1:1000 - 1:5000; IP: 1:40; ICC/IF: 1:50; IHC-P: Use at an assay dependent concentration
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant a
Alternative NameGP145-TrkB; trk-B; TRKB
Database LinkNP_006171
Entrez Gene 4915 Human
Entrez Gene 18212 Mouse
Entrez Gene 25054 Rat
FunctionThere is increasing evidence that neutrophins and their receptors play an important role in regulating development of both the central and the peripheral nervous systems (1). The binding of neurotrophin ligands to their respective Trk cellular receptors initiates intracellular signals essential for the growth and survival of neurons. The site of neurotrophin binding has been located to the fifth extracellular domain of the Trk receptor, with this region regulating both the affinity and specificity of Trk receptor:neurotrophin interaction (2). The TrkB receptor tyrosine kinase and its ligand, BDNF, have an essential role in certain forms of synaptic plasticity. Results provide evidence that TrkB mediates hippocampal plasticity via recruitment of PLCgamma, and by subsequent phosphorylation of CaMKIV (3). Also, TrkB has been found to be essential to the development of GABAergic neurons and regulates synapse formation in addition to its role in the development of axon terminals (4).
Related Pathway
MAPK signaling pathway

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IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TrkB (phospho Y817) [EP1298Y] antibody; TA301025 staining TrkB (phospho Y817) inmouse spinal cord tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 1% BSA for 10 minutes at 21°C; antigen retrieval was by heat mediation with citric acid. Samples were incubated with primary antibody (1/50 in TBS/BSA/azide buffer) for 16 hours at 21°C. A Biotin-conjugated Goat anti-rabbit IgG polyclonal (1/250) was used as the secondary antibody.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TrkB (phospho Y817) antibody [EP1298Y]; TA301025 staining TrkB (phospho Y817) in Rat spinal cord tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 1% BSA for 10 minutes at 21°C; antigen retrieval was by heat mediation in a citrate buffer. Samples were incubated with primary antibody (1/500 in TBS/BSA/azide buffer) for 16 hours at 21°C. A Biotin-conjugated Goat anti-rabbit IgG polyclonal (1/250) was used as the secondary antibody.

 

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