Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b
Synonyms:
GP145-TrkB; trk-B; TRKB
Immunogen
A phospho specific peptide corresponding to residues surrounding Tyrosine 817 of human TrkB was used as an immunogen. This antibody detects TrkB phosphorylated at Y817.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
There is increasing evidence that neutrophins and their receptors play an important role in regulating development of both the central and the peripheral nervous systems (1). The binding of neurotrophin ligands to their respective Trk cellular receptors initiates intracellular signals essential for the growth and survival of neurons. The site of neurotrophin binding has been located to the fifth extracellular domain of the Trk receptor, with this region regulating both the affinity and specificity of Trk receptor:neurotrophin interaction (2). The TrkB receptor tyrosine kinase and its ligand, BDNF, have an essential role in certain forms of synaptic plasticity. Results provide evidence that TrkB mediates hippocampal plasticity via recruitment of PLCgamma, and by subsequent phosphorylation of CaMKIV (3). Also, TrkB has been found to be essential to the development of GABAergic neurons and regulates synapse formation in addition to its role in the development of axon terminals (4).
Related Pathway
MAPK signaling pathway
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot analysis on rat brain lysates using anti-Phospho-TrkB (pY817), 1:10,000 dilution. Lysates were either (A) untreated or (B) treated with AP.
Researchers who bought this antibody have also purchased:
